Find the best NFL bets today - Sept. 10, 2026. Free expert and computer picks for every NFL game. Predicted Score 21.62 @ ⯆ 28.09 49ers vs Rams · Prediction & Game Odds Predicted Score 49ers are 6-0-1 ATS in their last 7 games as a favorite. 49ers are 5-1-1 ATS in their last 7 games on grass. Over is 4-1 in 49ers last 5 vs. NFC West. 49ers are 6-2-1 ATS in their last 9 games overall. Over is 4-0 in Rams last 4 vs. NFC West. Over is 4-0 in Rams last 4 games as an underdog. Under is 4-0 in Rams last 4 games in Week 1. Over is 8-1 in Rams last 9 games overall. Predicted Score 22.15 @ ⯆ 22.40 Bears vs Panthers · Prediction & Game Odds Predicted Score Over is 7-2-1 in Bears last 10 road games. Bears are 4-1-1 ATS in their last 6 games as an underdog. Under is 4-1 in Bears last 5 games as a favorite. Over is 6-2-1 in Bears last 9 games as a road underdog. Under is 4-1 in Panthers last 5 games overall. Under is 4-1 in Panthers last 5 vs. NFC. Panthers are 11-2 ATS in their last 13 games as a home underdog. Panthers are 4-1 ATS in their last 5 games on grass. Predicted Score 23.39 @ ⯆ 25.25 Ravens vs Colts · Prediction & Game Odds Predicted Score Over is 7-0 in Ravens last 7 games as a road underdog. Over is 4-0 in Ravens last 4 games in September. Over is 8-2 in Ravens last 10 games as an underdog. Over is 4-1 in Ravens last 5 games overall. Colts are 0-4 ATS in their last 4 home games. Colts are 0-4 ATS in their last 4 games as a favorite. Over is 9-3 in Colts last 12 games as a favorite. Colts are 5-1 ATS in their last 6 games in September. Predicted Score 21.54 @ ⯆ 21.77 Falcons vs Steelers · Prediction & Game Odds Predicted Score Falcons are 5-0 ATS in their last 5 games as a road underdog. Falcons are 7-1 ATS in their last 8 games as an underdog. Falcons are 5-1 ATS in their last 6 road games. Over is 5-1 in Falcons last 6 games as an underdog. Under is 6-1 in Steelers last 7 games in Week 1. Steelers are 5-1 ATS in their last 6 games as a home favorite. Under is 4-1-1 in Steelers last 6 home games. Under is 4-1-1 in Steelers last 6 games as a favorite. Predicted Score 17.08 @ ⯆ 23.48 Browns vs Jaguars · Prediction & Game Odds Predicted Score Over is 4-0 in Browns last 4 games as a favorite. Over is 6-1 in Browns last 7 games as a road favorite. Browns are 5-1 ATS in their last 6 vs. AFC. Under is 5-1 in Browns last 6 games as a road underdog. Jaguars are 8-1 ATS in their last 9 games overall. Jaguars are 7-1 ATS in their last 8 vs. AFC. Jaguars are 7-1 ATS in their last 8 games on grass. Jaguars are 5-1 ATS in their last 6 games as a home favorite. Predicted Score 21.29 @ ⯆ 25.43 Buccaneers vs Bengals · Prediction & Game Odds Predicted Score Under is 4-0 in Buccaneers last 4 games as a road favorite. Buccaneers are 4-0 ATS in their last 4 games in Week 1. Under is 5-1 in Buccaneers last 6 road games. Under is 4-1 in Buccaneers last 5 games on fieldturf. Under is 5-0 in Bengals last 5 games on fieldturf. Under is 4-0 in Bengals last 4 home games. Under is 4-0 in Bengals last 4 games in Week 1. Under is 4-1 in Bengals last 5 games as an underdog. Predicted Score ⯆ 18.69 @ 18.61 Jets vs Titans · Prediction & Game Odds Predicted Score Over is 5-0 in Jets last 5 games on grass. Over is 5-1 in Jets last 6 games overall. Over is 5-1 in Jets last 6 games as a favorite. Over is 5-1 in Jets last 6 games as an underdog. Under is 6-0 in Titans last 6 games in Week 1. Over is 4-1 in Titans last 5 games overall. Over is 4-1 in Titans last 5 games on grass. Under is 16-5-2 in Titans last 23 games as a home favorite. Predicted Score 20.10 @ ⯆ 29.12 Saints vs Lions · Prediction & Game Odds Predicted Score Saints are 6-0 ATS in their last 6 games overall. Saints are 5-0 ATS in their last 5 road games. Saints are 5-0 ATS in their last 5 games as an underdog. Saints are 4-0 ATS in their last 4 games as a road underdog. Lions are 8-1 ATS in their last 9 games as a home underdog. Over is 6-1 in Lions last 7 games as a favorite. Lions are 4-1 ATS in their last 5 games in Week 1. Over is 12-3 in Lions last 15 games in Week 1. Predicted Score 24.65 @ ⯆ 24.70 Bills vs Texans · Prediction & Game Odds Predicted Score Over is 5-1 in Bills last 6 vs. AFC. Over is 4-1 in Bills last 5 games as a favorite. Over is 5-2 in Bills last 7 games overall. Under is 9-4 in Bills last 13 games in Week 1. Under is 7-0 in Texans last 7 games in September. Texans are 5-1 ATS in their last 6 games as an underdog. Texans are 5-1 ATS in their last 6 games as a home underdog. Over is 4-1 in Texans last 5 home games. Predicted Score 18.55 @ ⯆ 25.74 Cardinals vs Chargers · Prediction & Game Odds Predicted Score Cardinals are 6-1 ATS in their last 7 games in Week 1. Over is 5-1 in Cardinals last 6 games as a favorite. Under is 11-2 in Cardinals last 13 games as a road favorite. Cardinals are 0-5 ATS in their last 5 games overall. Under is 4-1 in Chargers last 5 games overall. Chargers are 4-1 ATS in their last 5 home games. Over is 4-1 in Chargers last 5 games as a home underdog. Chargers are 10-2-2 ATS in their last 14 games in Week 1. Predicted Score 24.39 @ ⯆ 25.22 Packers vs Vikings · Prediction & Game Odds Predicted Score Over is 6-0 in Packers last 6 games as a road favorite. Over is 4-0 in Packers last 4 games as a favorite. Packers are 5-1-1 ATS in their last 7 vs. NFC North. Over is 7-2 in Packers last 9 road games.

Under is 5-0 in Vikings last 5 home games. Vikings are 4-0-1 ATS in their last 5 games overall. Vikings are 4-0-1 ATS in their last 5 vs. NFC. Vikings are 4-0-1 ATS in their last 5 games on fieldturf. Predicted Score 19.60 @ ⯆ 22.69 Dolphins vs Raiders · Prediction & Game Odds Predicted Score Over is 5-0-2 in Dolphins last 7 road games. Over is 4-0-2 in Dolphins last 6 games as a road underdog. Over is 3-0-1 in Dolphins last 4 vs. AFC. Under is 5-1-2 in Dolphins last 8 games on grass. Under is 4-0 in Raiders last 4 games in Week 1. Under is 4-1 in Raiders last 5 games as a favorite. Over is 4-1 in Raiders last 5 games as a home underdog. Raiders are 5-2 ATS in their last 7 vs. AFC. Predicted Score 19.34 @ ⯆ 23.63 Commanders vs Eagles · Prediction & Game Odds Predicted Score Over is 5-0 in Commanders last 5 vs. NFC East. Over is 4-0 in Commanders last 4 games overall. Over is 4-0 in Commanders last 4 vs. NFC. Over is 4-0 in Commanders last 4 games as an underdog. Eagles are 6-0 ATS in their last 6 games as an underdog. Over is 4-0 in Eagles last 4 games as a home underdog. Under is 4-1 in Eagles last 5 home games. Over is 4-1 in Eagles last 5 vs. NFC East. Predicted Score ⯆ 25.46 @ 23.00 Cowboys vs Giants · Prediction & Game Odds Predicted Score Over is 7-0 in Cowboys last 7 road games. Over is 5-0 in Cowboys last 5 games as a favorite. Over is 4-0 in Cowboys last 4 vs. NFC. Over is 4-0 in Cowboys last 4 games as a road favorite. Over is 5-0 in Giants last 5 vs. NFC East. Under is 6-0 in Giants last 6 games in Week 1. Over is 6-1 in Giants last 7 games overall. Over is 7-1 in Giants last 8 games on fieldturf. Predicted Score ⯆ 22.44 @ 21.56 Broncos vs Chiefs · Prediction & Game Odds Predicted Score Broncos are 5-0 ATS in their last 5 games as an underdog. Under is 4-0 in Broncos last 4 games as a road underdog. Under is 6-1 in Broncos last 7 vs. AFC West. Under is 6-1 in Broncos last 7 games as an underdog. Over is 10-1 in Chiefs last 11 games in Week 1. Chiefs are 4-1 ATS in their last 5 games as a home underdog. Under is 16-5 in Chiefs last 21 vs. AFC West. Chiefs are 21-7-1 ATS in their last 29 games as an underdog. Is there anything more beautiful than CMC checkdowns? The man was the entire offense last year, and while that type of workload probably isn't in the cards for him this season, I think five receptions out of the backfield/slot is definitely in play tonight. Purdy simply loves his safety blanket, and he won't shy away from him in a neutral-site game in Australia. McCaffrey went over this number in 13 regular-season games last year; if Myles Garrett and that Rams defensive line pressure Purdy like we all know that unit can, expect McCaffrey to gobble up receptions all night. Puka went over this number in nine games last season, reaching double-digit targets 10 times. If we see that type of volume again tonight, he should have no problem reaching the 100-yard milestone. Taking a step back, Nacua is averaging 95.3 receiving yards per game in the regular season - the best mark in NFL history. Against the 49ers, with a secondary that owned a 52.3 overall PFF grade in 2025 (third-lowest of any secondary in football), I'll ride with Nacua to put on a show in Melbourne. The gap between Colston Loveland's TD market implied probability (32%) and his actual chance of scoring (fair around 40%) is a big Week 1 advantage for early bettors. Loveland averaged 66 yards per game after Week 8 last season while adding touchdowns in five of those games (six total). Wide receiver Rome Odunze (leg) suffered his injury last Thursday and didn't practice Tuesday, while Luther Burden has been out for about a month with a groin injury and is working his way back to practice this week. It's the perfect spot at the wrong price for Caleb Williams' favorite target over the second half of last season. Williams finished last year with the third-highest deep-throw rate, and Loveland, who doesn't drop balls and played 40% of his snaps in the slot or out wide, could take full advantage as the healthiest pass catcher on the roster. The Panthers have a strong defensive line and a linebacker corps that is rebuilt with veteran star power. They should be able to control the Bears' run game and put pressure on Caleb Williams. The young quarterbacks on both sides could have long days. Lamar Jackson faces a blast from AFC North past when he and the Ravens take on the Colts and DC Lou Anarumo in Week 1. During his tenue with Cincinnati, Anarumo couldn’t slow down Jackson consistently and the Ravens QB chewed up his blitz-heavy schemes. Jackson recorded several multi-TD passing games versus those Bengals teams and constantly ranks out among the best QBs vs. blitz in the NFL. New Baltimore OC Declan Doyle got to work against two blitz-centric foes in joint practices this summer – Washington and Minnesota – ironing out the wrinkles against similar pressure before this Week 1 outing. I like Lamar to make Indy pay with two or more passing TDs. Bought at x3.7. Fair at x3.15. The Jaguars are trying to get Brian Thomas going after the disaster that was last season, and those moves might revive the burner. Thomas was useless over the middle under first-year offensive coach Liam Coen who is pushing him to the “X” receiver and using him more like the vertical threat he was in his rookie year. Travis Hunter is still not a major threat so last year’s setup with Jakobi Meyers and Parker Washington will still be the norm for Thomas who has had a leadup to the season. Cleveland is obviously without Mykles Garrett, but this is still a great defense, however, it’s not a bad one to attack early as it will be learning a new scheme under first-year DC Mike Rutenberg who replaces Jim Schwartz after he bailed on the organization after not getting the HC job. If he looks good in Week 1, bettors will never see a payout like this all season. The Cleveland Browns enter the year with massive questions on offense, with PFF rating them dead last in its offensive power rankings, though they remain solid on defense. With two solid defenses and Cleveland's atrocious offense, this promises to be one of the lowest-scoring games of Week 1. I like the Under at totals down to 38.5 points. With former WR Mike Evans no longer on the team, I'm betting on Irving getting a bigger role in Tampa Bay's offense this season. Baker played through injury most of last season and he still ran for +16 yards in 10 games. The Titans defense is a work in progress and Saleh’s trying the plug the gaps with familiar faces, including five former members of Gang Green. New York also have caught a break with Tennessee’s top tackler LB Cedric Gray crashing his UTV and suffering a concussion. There’s plenty of tape on Saleh’s schemes lying around East Rutherford, which helps new offensive coordinator Frank Reich ready his gameplan. New York has promising players at the skill positions and an offensive line looking to build on a better second half of 2025. New York opened +3 back in the spring and offseason action has trimmed this down to +1.5. It would seem Robert Saleh isn’t the only one who believes in the Jets offense. Here is another long shot that has my attention because of the possible heavy sets the Lions might run this year under new OC Drew Petzing. While in Arizona, he ran 2-TE sets at the sixth-highest rate in the league, and 3-TE sets at the highest rate. That playbook alone should get Brock Wright, who was already playing 35+ snaps last season, on the field more. Over the last two seasons, 15 of 33 passes inside the 5-yard line for Petzing's Cardinals went to a tight end. Ty Conklin is behind him on the depth chart, but he also just signed on September 1. The real bread and butter is the health of Sam LaPorta, who is dealing with a hip injury. He missed every preseason game and could be on a snap count early in the season after missing the second half of last year. Keep an eye on LaPorta's practice reps today, because Wright is lying in the weeds with a TE-heavy offense at a huge price. Just a half-unit here. The Lions have led the NFL in home scoring in back-to-back seasons and are coming off a year in which they averaged 32.5 points per game in Detroit. While they should be able to do a lot of the heavy lifting to push this game Over 48.5, don't sleep on the Saints offense who made some major upgrades this offseason. Kellen Moore has been the arcitect of some great offenses on his way to becoming head coach of New Orleans. Expect his strengths to be on full display with a talented group of playmakers at his disposal. I bought this at -120 but have the fair price closer to -150. It's Week 1, and I want a layup to get on the board. I don't see many running backs as likely to score Sunday as David Montgomery. The Bills gave up a league-high 18 TDs to opposing running backs last year and are a worse unit this season after losing five starters and bringing in a new defensive scheme. The Texans were one of the worst teams near the goal line last season, and they'll make it a point to change that narrative this year with their new back. Montgomery should get the majority of the red-zone work, and Houston can flirt with four TDs. The Texans were active in the offseason, bolstering their dog poo O-line and adding a steady rushing threat in David Montgomery. QB C.J. Stroud got the vote of confidence at QB (for at least one more year) and should improve given the better talent around him. For Buffalo, Josh Allen gets a true No. 1 receiver in D.J. Moore, who could show out in his Buffalo debut, as his career numbers spike when he plays indoors (I’ll be sniffing around his Week 1 props as well). Murray has a good idea of the defense he’ll face in Week 1. He played it every day in practice for the past three years. Former Arizona coach Jonathan Gannon is the new defensive coordinator in Green Bay. On top of being able to find Jefferson and Jordan Addison for deep TD connections, Murray’s ability to make plays outside the pocket gives O’Connell a new twist inside the 20-yard line. He has excellent jump ball options in burly WR Jauan Jennings and TE T.J. Hockenson. Projections tick as high as 1.6 TD passes and isn’t here just to hand the ball off. I’d play his 2+ touchdowns as high as 48%. Let’s not get fancy here. I’ll trade Justin Jefferson to find the end zone up to 40% in Week 1. His current TD market is tempered due to the mystery around new QB Kyler Murray and just two touchdown strikes in 2025. Despite poor passing, J.J. still ranked 10th versus zone coverage in 2025 at PFF and will face those schemes from new Packers DC Jonathan Gannon. Murray’s mobility and arm strength is excellent against zone and he’ll look to get Jefferson going early. Projections for Jefferson give between a 40% and 50% chance of “griddy” on Sunday. I bought this at 10.5x with a fair price of 7.5x. This one is all about the price, as 9.5% or 10.5x is simply far too much for a starting wide receiver on any team, let alone one facing the Dolphins. Jack Bech secured the No. 3 receiver spot behind Tre Tucker and Jalen Nailor. He's projected for just a couple of catches and 23 yards, but this is the price of a WR5, a player likely to see 10-15 snaps, not someone who is likely to see 30+ like Tyler Lockett did a season ago. This is a long shot for a reason, but one that should be priced closer to 6.5x. If you want more action in this game, keep an eye on the Raiders' tight end usage, as Klint Kubiak used 12 personnel at the fifth-highest rate last year. Michael Mayer (7x for a TD) could see a bigger role. This is the highest-rated touchdown at this probability, according to Covers' new Anytime Touchdown Value Index. Just another tool to help you sort through the noise, get to your pick a lot quicker, and give you back your time. There isn't a category across the many inputs where Dallas Goedert isn't showing value. I know matching last year's 11 TDs will be tough, but the matchup, scoring environment, red-zone role, role certainty, and relative price are all pointing to a buy in Week 1. He scores an 80 on the CATVI. It could be a better passing offense, with more looks under center for Jalen Hurts, while the loss of A.J. Brown opens up more targets for the tight end. I’m anticipating Diggs serving as a security blanket for quarterback Jayden Daniels early and often in the season opener, and with Washington a healthy underdog, the Commanders won’t have the luxury of abandoning the passing attack. Diggs was also sneaky good last season and finished 14th in PFF receiving grade while pacing the league in reception percentage among wideouts with at least 50 targets. New OC Matt Nagy wants Dart to take more snaps under center. That’s a big change from his college days and first year in the pros, with Dart primarily working out of the shotgun. Taking away that buffer will be a hard habit to break for the second-year QB. Throw at him a Dallas front that ranked tops in pressure rate last season, and Dart will lose his cool and opt to tuck and run rather than stand in the pocket. On top of getting his number called for carries, my projections sit at 32+ yards with some models as high as 36 rushing yards from Dart. Pickens is one of the best receivers versus zone coverage (rated 10th at PFF in 2025) and faces a zone-centric scheme from Wilson’s defense tonight. Six of his nine scores came against zone last year. Given Week 1 projections, I’d play Pickens 1+ touchdown as high as 45%. Expect the Broncos to test Mahomes’ mobility with their vaunted pass rush. Denver is a Top 5 stop unit, anchored in pressure. The last thing defensive coordinator Vance Joseph wants is to allow Mahomes to get comfortable in his return. An ailing offensive line could compound things for Kansas City. Guard Trey Smith has been limited by a hip injury all summer and admitted he’s not 100% heading into the opener. On the other side of the line, tackle Josh Simmons could sit Week 1 due to a back injury. Sprinkle in the possibility of slick field conditions, with thunderstorms around Arrowhead on Monday, and Denver will dampen Mahomes’ miraculous return to action. I bought this at 3x with a fair price of 2.7x. I want this new deep connection to work, and if the talk out of camp is true, this is going to be a great price. Bo Nix knows how to avoid sacks, and Waddle's 13.06 aDOT last year would have led the Broncos. Nix just needs to improve his deep ball, which ranked in the bottom third of the league last year. He still managed to throw for nearly 4,000 yards, and hopefully new playcaller Davis Webb can get more out of his QB. Meanwhile, the Chiefs lost three of their four leading snap-getters in the secondary, including CB Trent McDuffie, S Bryan Cook and CB Jaylen Watson. There's plenty of uncertainty in this new secondary, and the early part of the season is likely the best time to fade it before DC Steve Spagnuolo works his magic. Our experts and prediction models are hard at work analyzing the data. Check back shortly for today's picks, or explore our Computer Picks for inspiration. Latest headlines Checkout latest headlines Read more Anytime TD Scorer Predictions: Top Touchdown Grades for Week 1 Our Anytime TD Value Index Reviews Every NFL Anytime TD Bet Read more NFL Moneyline Picks for Every Week 1 Game Cowboys set the tone at MetLife. Read more Week 1 Predictions: Underdog Picks Against the Spread Baker need backup versus the Bengals. Read more 49ers vs Rams Prediction, Picks & Odds for Thursday Night Football Tonight Healthy 49ers can upset rival Rams. Read more Visit all available NFL odds View now NFL Odds NFL Scores + Matchups View now NFL Scores + Matchups Latest headlines Checkout latest headlines Read more Anytime TD Scorer Predictions: Top Touchdown Grades for Week 1 Our Anytime TD Value Index Reviews Every NFL Anytime TD Bet Read more NFL Moneyline Picks for Every Week 1 Game Cowboys set the tone at MetLife. Read more Week 1 Predictions: Underdog Picks Against the Spread Baker need backup versus the Bengals. Read more 49ers vs Rams Prediction, Picks & Odds for Thursday Night Football Tonight Healthy 49ers can upset rival Rams. Read more For every matchup in an NFL season, our NFL computer produces selections for a variety of different betting angles. Our computer picks are based on a proprietary algorithm that values each team in the current week to produce moneyline, spread, and point total selections. The table above, below the game picks, tracks our NFL computer's results over the last 100 games, outlining the record and profit for selections, based on $100 unit size. We track the profit based on both opening and closing lines for every matchup. How to Use NFL Computer Picks The easiest way to utilize our computer picks is to simply follow our selections for every matchup, what you'd call ailing the computer." But there are other ways to utilize our NFL computer picks, as well. You can use our NFL computer as a jumping-off point to do more research into specific lines, cross-referencing with expert picks, which can be found above the selections for some matchups, recent NFL betting trends , and more. As well, you can gauge the confidence of the matchup. The larger the projected score, the more confident the computer is in a specific pick. Or, if you want to implement a system, betting only on underdogs, for example, you can look for matchups in which our computer likes the underdog to inform which picks you're going to hone in on for a given week. We have these computer picks for every sport you're looking to wager on, as well: Free Computer Picks by Odds Shark College Football Picks College Basketball Picks NFL moneyline picks are the simplest way to get in on the NFL action. All you have to do is simply bet on which team you think will win the game. For moneyline picks, the favorite is represented with a minus sign (-) in front of the odds, while the underdog has a plus (+). However, you don't get the same profit for picking an underdog compared to a favorite. If the favored team is -120, a $100 bet on them would pay out $80 in profit and $180 total, if they win the game. The underdog winning at +150 would pay out a $150 profit, $250 total. We have a complete breakdown of how to read NFL moneyline odds for these NFL computer picks. While moneyline picks are the simplest, picking NFL games against the spread is probably the most common wager for regular NFL bettors. To bet an NFL spread, you wager on whether a team will win by a certain number of points or more or if they'll lose by fewer points than the spread. For example, if the spread is -6.5 for the New England Patriots, you would win the bet if they win the game by 7 points or more. Or if a team is +6.5, you're betting on if they'll win outright or lose by fewer than 6.5 points. There is a correlation between moneyline odds and the spread, as books set these lines based on the same information. You can read more about NFL spreads here . Totals (Over/Under) If you aren’t entirely sold on which NFL team will win or cover in an NFL game, you can still use our NFL computer picks to bet on the point total . As opposed to taking a side, in total or Over/Under betting, you wager on whether both NFL teams will combine for a final score of more than (Over) or less than (Under) the total number of points set by oddsmakers. The computer picks, and your handicapping of totals is more about how you think both teams will score points, not which team has the edge to win. More NFL Picks & Betting Tools Our NFL Computer Picks are a great way to place weekly football wagers, but you should also consider handicapping games yourself using some of our other tools. If you're looking to bet on long-term futures this football season, check out some of our other dedicated pages: NFL Consensus Picks Super Bowl Odds Super Bowl Halftime Show Odds NFL Rookie of the Year Odds Best Football Betting Sites If you’re ready to bet on NFL picks, you first need to find the right sportsbook. Our NFL betting sites guide offers secure banking, the best odds, bonuses, and reliable customer service options for you. NFL Free Picks FAQs Covers NFL picks are released two to three days before each game on the NFL schedule. Covers provides free NFL picks covering many markets, including point spreads, totals, moneylines, player props, and more.